Antibiotics Resistance among Nosocomial Burkholderia cepacia Isolates Detected in Sebha, Libya

Antibiotics Resistance among Nosocomial Burkholderia cepacia Isolates Detected in Sebha, Libya

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Background: B.cepacia complex (Bcc) is an emerging pathogenic organism that can cause many nosocomial infections among hospitalized patients.Inadequate laboratory facilities for B.cepacia complex detection and subsequently inappropriate treatment are considered a major cause for poor therapy outcomes.Methods: This project was aimed to investigate phenotype production of ESBL, AmpC, and Carbapenemase among 47 B.

cepacia complex isolated from different Sebha health care facilities.Results: Our data showed that 44.68% were ESBL producers, grandpas best 57.44% were AmpC producers, while only 29.78% produced carbapenemase.

In this study, antibiotics susceptibility of Bcc isolates was variable, 100 sophie allport zebra % resistant to Ticarcillin/clavulanic acid, 85 % resistant to sulfamethoxazole-trimethoprim, 76 % resistant to Ticarcillin/clavulanic Chloramphenicol, 57 % to Ceftazidime, and 55 % to Tetracyclines, 44% to Ciprofloxacin and 31% to Meropenem.Conclusion: In conclusion, this study shows that Bcc species have a higher resistance level attributed to several mechanisms.This high resistance needs careful antimicrobial prescribing regulations, and urgent implementation of infection prevention control is necessary.